Elsevier

Medical Hypotheses

Volume 21, Issue 2, October 1986, Pages 193-200
Medical Hypotheses

Multiple sclerosis: Decreased relapse rate through dietary supplementation with calcium, magnesium and vitamin D

https://doi.org/10.1016/0306-9877(86)90010-1Get rights and content

Abstract

A group of young patients having multiple sclerosis was treated with dietary supplements containing calcium, magnesium and vitamin D for a period of one to two years. The experimental design employed self-pairing: the response of each patient was compared with his/her own case history as control. The number of exacerbations observed during the program was less than one half the number expected from case histories. No side effects were apparent. The dietary regimen may offer a new means of controlling the exacerbation rate in MS, at least for younger patients. The results tend to support a theory of MS which states that calcium and magnesium are important in the development, structure and stability of myelin.

References (10)

  • MS Seelig

    The requirement of magnesium by the normal adult

    Amer J. Clinical Nutrition

    (1964)
  • P Goldberg

    Multiple sclerosis: vitamin D and calcium as environmental determinants of prevalence. Part 1: Sunlight, dietary factors and epidemiology

    Intern. J. Environmental Studies

    (1974)
  • P Goldberg

    Multiple sclerosis: vitamin D and calcium as environmental determinants of prevalence. Part 2: Biochemical and genetic factors

    J. Environmental Studies

    (1974)
  • PI Yakovlev

    Morphological criteria of growth and maturation of the nervous system of man

    Mental Retardation

    (1962)
  • PI Yakovlev et al.

    The myelogenetic cycles of regional maturation of the brain

There are more references available in the full text version of this article.

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