Aspirin intolerance in asthma: Detection by oral challenge☆,☆☆
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Inhaled drug delivery for the targeted treatment of asthma
2023, Advanced Drug Delivery ReviewsEffect of LTRA in L-ASA Challenge for Aspirin-Exacerbated Respiratory Disease Diagnosis
2021, Journal of Allergy and Clinical Immunology: In PracticeGenetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease
2016, Immunology and Allergy Clinics of North AmericaCitation Excerpt :The gold standard for diagnosis of AERD is oral aspirin challenge to provoke symptomatic response.91 During this response, CysLT production is dramatically increased, precipitating symptoms.88,89,91,92 After diagnosis, significant improvement in asthma symptoms and slowing of NP recurrence are achieved with aspirin desensitization and daily high-dose aspirin treatment.90
Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature
2015, Journal of Allergy and Clinical ImmunologyCitation Excerpt :After database search and removal of duplicates, a total of 159 articles were identified for full-text review (Fig 1). These were assessed on the basis of inclusion/exclusion criteria, and a manual search was performed on all references of chosen studies, resulting in a total of 27 studies; the characteristics of these studies are listed in Table II.1-3,9-32 Of those in which oral challenges were performed (n = 6), 3 were single blind, 1 was open, and in 2 the blinding was not specified.
Use of nasal inspiratory flow rates in the measurement of aspirin-induced respiratory reactions
2013, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Aspirin-exacerbated respiratory disease (AERD) is an aggressive inflammatory disease that consists of chronic hyperplastic eosinophilic sinusitis and nasal polyposis, asthma, and aspirin hypersensitivity.1 Although the prevalence of AERD ranges in all asthmatics from 7% to 10.6%, it may be up to 19.5% in patients with pansinusitis and nasal polyposis, making it a relatively common and important diagnosis that pulmonologists and allergists must consider.2,3 Although it has been previously shown that aspirin desensitization can improve different clinical outcomes, it is underused because it is time consuming and occasionally causes severe bronchospasm and adverse extrapulmonary effects.4-6
The prevalence of aspirin-induced asthma in Saudian asthmatic patients
2010, Allergologia et Immunopathologia
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Supported in part by Grant, No. AI-00214 and AI-10386 from the National Institutes of Health.
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Presented in part at the Annual Meeting of the American Academy of Allergy, San Francisco, Calif., February 7, 1972.
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United States Army-sponsored Allergy Fellowship Trainee.