Research paperSerum lipids, lipoprotein lipids and coronary heart disease in patients with xanthelasma palpebrarum
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Xanthelasma Palpebrarum: An Oculoplastic Viewpoint of Optimal Treatment
2021, Advances in Ophthalmology and OptometryCitation Excerpt :On average, approximately 50% of patients with XP are hyperlipidemic and the other half are normolipidemic (ranges from 25% to 70%), defined as normal cholesterol and triglyceride levels [2,7–9]. Among the hyperlipidemic patients, the most frequent Fredrickson hyperlipidemic phenotype is type IIa, which is expressed as elevated low-density lipoprotein (LDL) cholesterol [10]. Among the normolipidemic patients, although blood lipid profile is in the normal range, the levels of LDL cholesterol and very low density lipoprotein have been shown to be significantly higher, and high-density lipoprotein (HDL) cholesterol levels and HDL/LDL ratio lower, than that of healthy controls [10,11].
Serum lipids and risk of atherosclerosis in xanthelasma palpebrarum: A systematic review and meta-analysis
2020, Journal of the American Academy of DermatologyCitation Excerpt :We initially identified 229 potentially relevant articles, of which 214 were excluded according to the 4-step process of identification, screening, eligibility, and inclusion to select studies for meta-analysis. Finally, 15 case-control studies (published in 1981-2016) with 854 patients with XP and 907 healthy controls were included in the quantitative analysis after sequential exclusion (Fig 1).10-24 Table I reports the characteristics of these studies.
Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications
2016, Ageing Research ReviewsCitation Excerpt :The coexistence of xanthelasmata and cardiovascular disease in some families was observed more than 60 years ago (McKinney, 1950; Weber, 1948). Since then, the association between xanthelasmata and increased risk of ischemic heart disease has been investigated in several studies with conflicting results (Bates and Warren, 1989; Chan et al., 2008; Epstein et al., 1952; Noel, 2007; Ozdol et al., 2008; Pandhi et al., 2012; Pedace and Winkelmann, 1965; Segal et al., 1986; Vacca et al., 1959; Watanabe et al., 1981). With one exception (Segal et al., 1986), these studies are based on very small sample sizes, thus probably lacking power to detect associations of moderate size.
Atypical lymphoid hyperplasia of the eyelids manifesting as xanthelasma- like lesions
1997, Journal of the American Academy of DermatologyLipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma
1995, The American Journal of MedicineXanthelasmas and xanthomas - cutaneous clues to systemic lipid disorders
1995, Clinical Eye and Vision Care