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Diabetes and disordered bone metabolism (diabetic osteodystrophy): time for recognition

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Abstract

Summary

Diabetes and osteoporosis are rapidly growing diseases. The link between the high fracture incidence in diabetes as compared with the non-diabetic state has recently been recognized. While this review cannot cover every aspect of diabetic osteodystrophy, it attempts to incorporate current information from the First International Symposium on Diabetes and Bone presentations in Rome in 2014.

Diabetes and osteoporosis are fast-growing diseases in the western world and are becoming a major problem in the emerging economic nations. Aging of populations worldwide will be responsible for an increased risk in the incidence of osteoporosis and diabetes. Furthermore, the economic burden due to complications of these diseases is enormous and will continue to increase unless public awareness of these diseases, the curbing of obesity, and cost-effective measures are instituted. The link between diabetes and fractures being more common in diabetics than non-diabetics has been widely recognized. At the same time, many questions remain regarding the underlying mechanisms for greater bone fragility in diabetic patients and the best approach to risk assessment and treatment to prevent fractures. Although it cannot cover every aspect of diabetic osteodystrophy, this review will attempt to incorporate current information particularly from the First International Symposium on Diabetes and Bone presentations in Rome in November 2014.

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Acknowledgments

We would like to thank the following speakers who participated in the First International Symposium on Diabetes and Bone in Rome in November 2014. We have included some of the content of their presentation in its original or modified form as a contribution in our review.

Bo Abrahamsen: Institute of Clinical Research, Research Centre for Ageing and Osteoporosis, Department of Medicine, Glostrup Hospital (Nord), Glostrup, Denmark;

Laurie Baggio: Mt. Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada;

Marco Baroni: Clinica Medica, Sapienza University of Rome, Rome, Italy;

Dennis Black: University of California San Francisco (UCSF), San Francisco, California, USA;

Henry Bone: Michigan Bone and Mineral Clinic PC, University of Michigan, Detroit, USA;

Roberto Civitelli: Division of Bone and Mineral Diseases Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, Missouri, USA;

Renate T. de Jongh: VU Medical Center Amsterdam, The Netherlands;

David Dempster: College of Physicians and Surgeons of Columbia University Regional Bone Center, Helen Hayes Hospital, New York State Department of Health, New York, USA;

Rivka Dresner-Pollack: Hadassah-Hebrew University Medical Center, Jerusalem, Israel;

Didier Hans: University of Lausanne, Lausanne, Switzerland;

Davide Lauro: University of Rome Tor Vergata, Rome, Italy;

Andrea Lenzi: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;

Laura Mc Cabe: Biomedical Imaging Research Center, Michigan State University East Lansing, MI, USA;

Silvia Migliaccio: University of Rome Foro Italico, Rome, Italy;

Geltrude Mingrone: Policlinico Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy;

Anne Schwartz: University of California San Francisco (UCSF), San Francisco, California, USA.

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    Authors and Affiliations

    1. Division of Endocrinology, Mount Sinai School of Medicine, New York, NY, USA

      S. Epstein

    2. Unit of Endocrinology and Diabetes, Department of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21-00128, Rome, Italy

      G. Defeudis, S. Manfrini, N. Napoli & P. Pozzilli

    3. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

      G. Defeudis

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    SE is a consultant for Merck and speaker for Merck and Takeda. GD receives travel grant from Itapharma. SM declares that she has no conflict of interest. NN has no conflict of interest. PP has received speaker honoraria and travel grants from Lilly, Astra Zeneca, Merck Sharp & Dohme, and Sanofi.

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    S. Epstein and G. Defeudis contributed equally to this work.

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    Epstein, S., Defeudis, G., Manfrini, S. et al. Diabetes and disordered bone metabolism (diabetic osteodystrophy): time for recognition. Osteoporos Int 27, 1931–1951 (2016). https://doi.org/10.1007/s00198-015-3454-x

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