Abstract
Neurologic examination, electrophysiologic testing and microscopic post-mortem examination was used to study the neuropathy induced in the beagle dog by administration of excessive amounts of vitamin B6.
Two female dogs received repeated daily oral doses of 3 g. The treatment was ceased when the dogs developed severe general morbidity, including uncoordinated gait and abnormal neurologic symptoms. The symptoms were most severe during and early after cessation of treatment, and in general they regressed during the subsequent 3 months of treatment-free observation. Sensory central and peripheral maximum nerve conduction velocity started to decrease after a considerable delay; the decrease progressed until late after termination of treatment and failed to fully regress. Morphologic lesions were confined to large, first order sensory neurons.
The neurologic examination thus revealed the early changes, while electrodiagnostics and microscopic neuropathology were indicators of more advanced stages of toxic neuropathy and disclosed selective lesions in individuals whose gait appeared to be unremarkable.
Similar content being viewed by others
References
G. Krinke, P. Thomann andR. Hess, Experimental toxic models of neurological disease. InAnimal Models of Neurological Disease. (Ed.F. Clifford-Rose andP.O. Behan). Pitman Medical Limited, Tunbridge Wells 1980).
G. Krinke, H.H. Schaumburg, P.S. Spencer, J. Suter, P. Thomann andR. Hess,Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog, Neurotoxicology2, 13–24 (1981).
R.W. Redding andK.G. Braund. InNeurological Examination in Canine Neurology, pp. 53–70. (Ed.B.F. Hoerlein). W.B. Saunders, Philadelphia 1978.
P. Oettli,Neurostatus: Untersuchungstechnik. Interpretation Neurologischer Befunde, Schweizerische Vereinigung für Kleintiermedizin Jahresversammlung 8.–9. Juni 1979, Zürich, pp. 9–29.
U. Schaeppi,Neurological examination of beagle dogs in toxicity studies, Lectures in Toxicology, (1982).
U. Schaeppi, M. Teste andU. Siegenthaler,Sensory and motor maximum nerve conduction velocity in the peripheral and central nervous system of the beagle dog, Agents and Actions12, 567–575 (1982).
G. Krinke, H.H. Schaumburg, P.S. Spencer, P. Thomann andR. Hess,Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog, Acta Neuropathologica47, 213–221 (1979).
T. Ruch andH.D. Patton,Physiology and Biophysics. The Brain and Neural Function. W.B. Saunders, Philadelphia 1979.
P.S. Spencer,A review of acrylamide neurotoxicity. Part II: Experimental animal neurotoxicity and pathologic mechanisms, Can. J. Neurol. Sci. 152–169 (1974). (1974).
A.G. Brown,Organization in the Spinal Cord. Springer, Berlin 1981.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schaeppi, U., Krinke, G. Pyridoxine neuropathy: Correlation of functional tests and neuropathology in beagle dogs treated with large doses of vitamin B6 . Agents and Actions 12, 575–582 (1982). https://doi.org/10.1007/BF01965944
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01965944