Summary
A recurring question appearing in clinical psychopharmacological research concerns the nature of the relationship between initial severity of symptomatology and the magnitude of a drug effect. Data are presented to show that, with meprobamate and placebo in neurotic outpatients, the magnitude of the pharmacological effect remains constant across all levels of initial severity.
References
Benjamin, L. S.: Statistical treatment of the Law of Initial Values (LIV) in autonomic research: a review and recommendation. Psychosom. Med. 25, 556–566 (1963).
Fisher, S., J. O. Cole, K. Rickels, and E. H. Uhlenhuth: Drug-set interaction: the effect of expectations on drug response in outpatients. Proceedings of the Third Collegium Internationale Neuropsychopharmacologicum (in press).
Gliedman, L. H., E. H. Nash, S. D. Imber, A. R. Stone, and J. D. Frank: Reduction of symptoms by pharmacologically inert substances and by short-term psychotherapy. Arch. Neurol. Psychiat. 79, 345–351 (1958).
Snedecor, G. W.: Statistical Methods, p. 394–400. Iowa State College Press 1956.
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These data were collected as part of an investigation supported by two special U.S.P.H.S. research grants to the University of Pennsylvania (MH-04731, Rickels) and to Johns Hopkins University (MH-04732, Uhlenhuth and Park); the over-all project was coordinated by the Psychopharmacology Service Center of N.I.M.H. (Fisher and Lipman). The three participating clinics were: Henry Phipps Psychiatric Clinic at Johns Hopkins, the Functional Clinic at the University of Pennsylvania, and the Neuropsychiatric Clinic at the Philadelphia General Hospital (Dr. John Mock was particularly helpful at PGH). Preparation of this report is in part supported additionally by MH-08954.
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Fisher, S., Lipman, R.S., Uhlenhuth, E.H. et al. Drug effects and initial severity of symptomatology. Psychopharmacologia 7, 57–60 (1965). https://doi.org/10.1007/BF00404165
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DOI: https://doi.org/10.1007/BF00404165