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Drug effects and initial severity of symptomatology

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Summary

A recurring question appearing in clinical psychopharmacological research concerns the nature of the relationship between initial severity of symptomatology and the magnitude of a drug effect. Data are presented to show that, with meprobamate and placebo in neurotic outpatients, the magnitude of the pharmacological effect remains constant across all levels of initial severity.

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References

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These data were collected as part of an investigation supported by two special U.S.P.H.S. research grants to the University of Pennsylvania (MH-04731, Rickels) and to Johns Hopkins University (MH-04732, Uhlenhuth and Park); the over-all project was coordinated by the Psychopharmacology Service Center of N.I.M.H. (Fisher and Lipman). The three participating clinics were: Henry Phipps Psychiatric Clinic at Johns Hopkins, the Functional Clinic at the University of Pennsylvania, and the Neuropsychiatric Clinic at the Philadelphia General Hospital (Dr. John Mock was particularly helpful at PGH). Preparation of this report is in part supported additionally by MH-08954.

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Fisher, S., Lipman, R.S., Uhlenhuth, E.H. et al. Drug effects and initial severity of symptomatology. Psychopharmacologia 7, 57–60 (1965). https://doi.org/10.1007/BF00404165

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  • DOI: https://doi.org/10.1007/BF00404165

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