Fig 8 Trial sequential analysis (cumulative meta-analysis) assessing effect of antithrombin III in critically ill patients with sample size adjusted for low bias heterogeneity. Cumulative z curve (red dashed line) does not cross trial sequential monitoring boundary (blue line) constructed for sample size of 14 294 patients, corresponding to relative risk reduction of 5% (from 48.5% to 46.2%) with α=0.05 and 80% power (β=0.20). Only 24% of required information size has been reached so far