Table 4

 Univariate and multivariate Cox regression analyses of baseline variables for patients alive at six months after randomisation into the first international stroke trial. Figures are hazard ratios (95% confidence intervals)

VariableUnivariate analysisMultivariate analysis
Age1.07 (1.06 to 1.07)***1.07 (1.06 to 1.07)***
Male sex0.97 (0.88 to 1.07)1.42 (1.28 to 1.58)***
Mean systolic BP1.00 (1.00 to 1.00)1.00 (1.00 to 1.00)
Atrial fibrillation1.64 (1.45 to 1.86)***1.16 (1.02 to 1.32)*
Visible infarct on CT0.95 (0.85 to 1.06)1.05 (0.94 to 1.17)
Antiplatelet use before stroke1.21 (1.08 to 1.35)*1.17 (1.04 to 1.31)*
Anticoagulant use before stroke 0.71 (0.35 to 1.42)0.62 (0.31 to 1.24)
Stroke syndrome†:
 LACI11
 PACI1.25 (1.09 to 1.42)*1.15 (1.01 to 1.31)*
 POCI0.98 (0.81 to 1.19)1.04 (0.86 to 1.26)
 TACI1.44 (1.24 to 1.66)***1.23 (1.06 to 1.43)*
 Indeterminate subtype0.28 (0.07 to 1.14)0.36 (0.09 to 1.43)
Functionally dependent (at six months)1.91 (1.68 to 2.16)***1.63 (1.43 to 1.85)***

CT=computed tomography; LACI=lacunar infarct; PACI=partial anterior circulation infarct; POCI=posterior circulation infarct; TACI=total anterior circulation infarct.

*P<0.05, ***P<0.001.

†Overall P values of stroke syndrome: univariate analysis P<0.01 and multivariate analysis P=0.03.