Table 4

Cost (£) per life year gained (unless stated otherwise) for various scenarios of full compliance with 40 mg simvastatin daily for the population of the heart protection study

Treatment Five year risk of major vascular event at start of treatment
12% 18% 22% 28% 42%
Lifetime use of generic simvastatin*
Age at start (years):
 40-49 −580 −1140 −1280 −1310 −1270
 50-59 −500 −830 −890 −990 −930
 60-69 −200 −480 −530 −580 −530
 ≥70 110 −100 −220 −250 −190
5 year use of generic simvastatin
Age at start (years):
 40-49 −1230 −1890 −2030 −2050 −1930
 50-59 −1010 −1330 −1380 −1470 −1350
 60-69 −600 −840 −870 −900 −800
 ≥70 −240 −410 −500 −520 −410
Lifetime use of proprietary simvastatin
Age at start (years):
 40-49 9260 6010 4710 3620 2610
 50-59 8720 6170 4900 3870 2860
 60-69 8470 6430 5230 4190 3040
 ≥70 8910 6910 5740 4610 3340

*Values are adjusted for age specific and sex specific health related quality of life.

Negative values indicate cost savings. £1=€1.5=$1.9.

All discounted at 3.5% per annum; 28 day pack of generic simvastatin at £4.87 and proprietary simvastatin at £29.69.