Table 2

 Outcome measures with full compliance with lifetime use of generic 40 mg simvastatin daily for the population of the heart protection study

Outcome Five year risk of major vascular event at start of treatment
12% 18% 22% 28% 42%
Life years gained
Age at start (years):
 40-49 0.62 0.81 0.94 1.08 1.24
 50-59 0.58 0.71 0.82 0.94 1.08
 60-69 0.50 0.58 0.66 0.75 0.88
 ≥70 0.38 0.45 0.50 0.57 0.68
Lifetime cost (£) of treatment with simvastatin
Age at start (years):
 40-49 1180 1100 1050 990 880
 50-59 1030 950 900 860 760
 60-69 840 780 730 680 590
 ≥70 670 620 580 540 460
Cost (£) of hospital admission due to simvastatin*
Age at start (years):
 40-49 −1450 −1810 −1970 −2080 −2100
 50-59 −1250 −1400 −1460 −1570 −1530
 60-69 −920 −980 −990 −1010 −950
 ≥70 −640 −650 −660 −650 −560
Cost (£) per life year gained
Age at start (years):
 40-49 −440 −880 −990 −1010 −990
 50-59 −370 −630 −680 −760 −720
 60-69 −140 −360 −400 −440 −400
 ≥70 80 −70 −160 −190 −140

Negative values indicate cost savings. £1=€1.5=$1.9.

All results discounted at 3.5% per annum; 28 day pack of generic simvastatin at £4.87.