Table 3

 Stratified analyses of relative risk of coronary heart disease and stroke

No of reports*Relative risk (95% CI)P for heterogeneityI2P for test
Coronary heart disease
 Total cases90.99 (0.85 to 1.15)0.970.00.88
 Fatal cases41.18 (0.71 to 1.96)0.910.00.53
 Coronary heart disease with diabetes†51.54 (1.14 to 2.09)0.590.00.01
Subgroup analyses for total coronary heart disease
Sex
 Male41.06 (0.89 to 1.25)0.830.00.53
 Female30.99 (0.83 to 1.20)0.990.00.95
Study location
 USA61.01 (0.90 to 1.13)0.960.00.89
 Asia30.95 (0.64 to 1.41)0.760.00.79
No of participants
 >10 00040.97 (0.81 to 1.15)0.870.00.70
 ≤10 00051.14 (0.83 to 1.56)0.930.00.42
No of cases
 >50041.00 (0.89 to 1.13)0.790.00.94
 ≤50050.96 (0.67 to 1.37)0.930.00.83
Duration of follow-up
 >15 years21.02 (0.89 to 1.16)0.400.00.83
 ≤15 years70.98 (0.81 to 1.19)0.980.00.85
Repeated egg consumption measurements
 Yes40.97 (0.81 to 1.15)0.870.00.70
 No51.14 (0.83 to 1.56)0.930.00.42
Study quality
 Score ≥850.97 (0.80 to 1.17)0.930.00.74
 Score <841.06 (0.88 to 1.28)0.810.00.55
Controlling for other diet variables in models‡
 Yes60.97 (0.82 to 1.15)0.970.00.73
 No51.14 (0.84 to 1.55)0.920.00.40
Controlling for serum cholesterol levels or use of cholesterol lowering drugs in models
 Yes50.97 (0.75 to 1.26)0.650.00.83
 No41.01 (0.86 to 1.18)0.970.00.94
Stroke
 Total stroke80.91 (0.81 to 1.02)0.460.00.10
 Fatal stroke40.94 (0.81 to 1.10)0.470.00.46
 Hemorrhagic stroke†30.75 (0.57 to 0.99)0.2136.80.04
 Ischemic stroke†40.91 (0.82 to 1.01)0.790.00.08
 Stroke with diabetes†30.80 (0.29 to 2.15)0.0958.90.65
Subgroup analyses for total stroke
Sex
 Male40.89 (0.77 to 1.03)<0.00190.50.13
 Female40.91 (0.77 to 1.07)0.2429.00.25
Study location
 USA50.90 (0.79 to 1.03)0.384.90.13
 Asia30.94 (0.83 to 1.07)0.2820.60.34
No of participants
 >10 00040.90 (0.80 to 1.02)0.2526.90.10
 ≤10 00040.97 (0.75 to 1.27)0.500.00.85
No of cases
 >50050.91 (0.81 to 1.02)0.385.00.09
 ≤50031.00 (0.63 to 1.59)0.354.20.99
Duration of follow-up
 >15 years50.91 (0.81 to 1.02)0.385.00.09
 ≤15 years31.00 (0.63 to 1.59)0.354.20.99
Repeated egg consumption measurements
 Yes30.90 (0.78 to 1.04)0.1351.50.14
 No50.94 (0.83 to 1.08)0.640.00.38
Study quality
 Score ≥7.551.03 (0.88 to 1.20)0.510.00.71
 Score <7.530.88 (0.77 to 1.01)0.820.00.07
Controlling for other diet variables in models‡
 Yes40.90 (0.79 to 1.04)0.2526.60.14
 No50.95 (0.83 to 1.08)0.620.00.43
Controlling for serum cholesterol levels or use of cholesterol lowering drugs in models
 Yes41.04 (0.91 to 1.18)0.3410.00.60
 No40.89 (0.77 to 1.01)0.940.00.07

*Five articles reported their results by sex group; therefore, there were nine reports from six articles for coronary heart disease and eight reports from six articles for stroke.

†Owing to a lack of data for person years, results are relative risks (95% confidence intervals) comparing highest with lowest egg consumption.

‡Study by Scrafford and colleagues reported results both controlling for diet variables and not.