Table 2

 Risk of cancer in offspring whose parents were affected with concordant cancer compared with offspring without affected parents. Figures are hazard ratios* (95% confidence interval)

Cancer and age (years) at diagnosis in offspringParental age (years) at diagnosis
<4040-4950-5960-6970-7980-89≥90All ages
Colorectal
0-768.3 (5.7 to 12.1)4.4 (3.6 to 5.4)2.8 (2.5 to 3.2)2.1 (2.0 to 2.3)1.7 (1.6 to 1.8)1.6 (1.4 to 1.7)1.6 (1.2 to 2.0)1.9 (1.8 to 2.0)
<609.9 (6.8 to 14.4)5.5 (4.4 to 6.8)3.4 (2.9 to 3.9)2.3 (2.0 to 2.5)1.9 (1.7 to 2.0)1.7 (1.5 to 1.9)1.3 (0.9 to 2.0)
60-761.2 (0.6 to 2.5)1.7 (1.4 to 2.2)1.8 (1.6 to 2.1)1.5 (1.3 to 1.6)1.5 (1.3 to 1.7)1.9 (1.3 to 2.6)
Lung
0-763.2 (0.8 to 12.7)1.3 (0.7 to 2.4)2.7 (2.3 to 3.2)2.0 (1.8 to 2.3)2.1 (1.9 to 2.3)1.8 (1.6 to 2.1)1.4 (0.7 to 2.8)2.1 (1.9 to 2.2)
<601.1 (0.5 to 2.4)3.2 (2.6 to 3.9)2.3 (2.0 to 2.7)2.2 (1.9 to 2.5)1.8 (1.4 to 2.3)1.8 (0.7 to 4.9)
60-761.3 (0.4 to 4.0)1.5 (1.1 to 2.1)1.4 (1.2 to 1.7)1.8 (1.5 to 2.0)1.8 (1.4 to 2.2)1.5 (0.6 to 4.1)
Breast
0-764.7 (3.9 to 5.7)2.9 (2.7 to 3.2)2.5 (2.3 to 2.6)2.0 (1.9 to 2.1)1.8 (1.7 to 1.9)1.6 (1.5 to 1.7)1.3 (1.0 to 1.6)2.0 (1.9 to 2.1)
<605.2 (4.4 to 6.3)3.0 (2.7 to 3.3)2.5 (2.3 to 2.7)2.1 (2.0 to 2.2)1.8 (1.7 to 1.9)1.5 (1.4 to 1.7)1.4 (1.1 to 1.7)
60-761.8 (1.3 to 2.3)1.5 (1.3 to 1.8)1.4 (1.3 to 1.6)1.5 (1.3 to 1.7)1.6 (1.4 to 1.8)1.4 (1.0 to 2.1)
Prostate
0-765.2 (2.5 to 10.9)3.3 (2.8 to 3.8)2.9 (2.8 to 3.1)2.4 (2.3 to 2.4)1.9 (1.8 to 2.0)1.3 (1.1 to 1.6)2.3 (2.2 to 2.4)
<607.8 (3.2 to 18.7)4.9 (3.9 to 6.0)4.1 (3.8 to 4.5)3.0 (2.8 to 3.3)2.2 (2.0 to 2.4)1.7 (1.1 to 2.6)
60-763.8 (1.0 to 15.2)2.3 (1.8 to 2.8)2.1 (2.0 to 2.3)1.9 (1.8 to 2.0)1.8 (1.7 to 1.9)1.4 (1.1 to 1.8)
Urinary bladder
0-763.8 (2.1 to 7.1)2.3 (1.7 to 3.2)2.2 (1.8 to 2.6)1.8 (1.6 to 2.1)1.9 (1.5 to 2.3)1.7 (1.0 to 3.1)2.0 (1.8 to 2.2)
<604.1 (2.0 to 8.1)2.3 (1.6 to 3.4)2.2 (1.7 to 2.8)1.7 (1.3 to 2.1)1.9 (1.5 to 2.5)2.1 (0.9 to 4.6)
60-761.7 (1.0 to 3.0)2.1 (1.6 to 2.8)1.9 (1.5 to 2.4)1.7 (1.2 to 2.3)1.4 (0.5 to 3.7)
Melanoma
0-765.4 (4.1 to 7.2)4.5 (3.7 to 5.5)3.7 (3.2 to 4.4)2.9 (2.5 to 3.4)2.2 (1.9 to 2.6)2.3 (1.9 to 2.8)0.5 (0.2 to 1.5)2.9 (2.7 to 3.2)
<605.8 (4.3 to 7.7)4.7 (3.8 to 5.8)3.7 (3.1 to 4.5)3.0 (2.6 to 3.5)2.0 (1.6 to 2.4)2.2 (1.8 to 2.9)0.5 (0.1 to 1.9)
60-762.2 (0.6 to 9.0)3.6 (2.0 to 6.4)2.0 (1.1 to 3.4)2.7 (1.8 to 3.9)2.0 (1.2 to 3.4)0.7 (0.1 to 4.8)
Skin squamous cell carcinoma
0-762.1 (0.5 to 8.4)1.8 (0.9 to 3.4)3.1 (2.3 to 4.1)2.4 (2.0 to 2.9)2.0 (1.7 to 2.4)1.9 (1.4 to 2.7)2.2 (2.0 to 2.5)
<602.9 (0.7 to 11.7)2.0 (0.9 to 4.4)3.3 (2.3 to 4.7)2.6 (2.0 to 3.3)1.5 (1.1 to 2.0)1.7 (1.0 to 2.9)
60-761.4 (0.4 to 4.2)2.4 (1.5 to 3.9)2.2 (1.6 to 2.9)2.6 (2.0 to 3.3)2.3 (1.5 to 3.5)
Non-Hodgkin’s lymphoma
0-761.9 (0.5 to 7.5)0.8 (0.3 to 2.6)2.3 (1.5 to 3.3)2.3 (1.8 to 3.0)1.4 (1.1 to 1.8)1.7 (1.3 to 2.3)0.9 (0.3 to 2.9)1.8 (1.5 to 2.0)
<602.0 (0.5 to 8.0)0.6 (0.2 to 2.5)2.4 (1.5 to 3.6)2.4 (1.8 to 3.1)1.3 (0.9 to 1.8)1.8 (1.2 to 2.5)
60-761.4 (0.5 to 4.4)2.0 (1.2 to 3.4)1.6 (1.0 to 2.5)1.4 (0.8 to 2.5)1.6 (0.4 to 6.4)

*Presented if at least two familial cases were available in that strata. Adjusted for age, sex, calendar period, geographical region, socioeconomic status of index cases as well as age at start and end of follow-up of parents; further adjustment for admission to hospital for obesity, chronic obstructive pulmonary disease (as proxy for smoking), and alcohol consumption did not change results.