Table 2

 Long term mortality from circulatory causes in women with pre-eclampsia during first singleton pregnancy

Outcome of first pregnancyNo of womenIschaemic heart disease (codes I20-I25)*Cerebrovascular disease (stroke, codes I60-I69)*All other circulatory causes
No of deaths (per 1000)Adjusted hazard ratio (95% CI)†No of deaths (per 1000)Adjusted hazard ratio (95% CI)†No of deaths (per 1000)Adjusted hazard ratio (95% CI)†
Women with one lifetime pregnancy
No pre-eclampsia, term birth112 208313 (2.8)2.0 (1.8 to 2.4)294 (2.6)1.9 (1.6 to 2.2)332 (3.0)2.0 (1.8 to 2.4)
Term pre-eclampsia475834 (7.1)4.7 (3.3 to 6.7)14 (2.9)2.1 (1.2 to 3.6)17 (3.6)2.4 (1.5 to 3.9)
Preterm pre-eclampsia142615 (10.5)9.3 (5.5 to 15.6)16 (11.2)10.4 (6.3 to 17.2)6 (4.2)3.6 (1.6 to 8.0)
Women with two or more lifetime pregnancies
No pre-eclampsia, term birth599 973675 (1.1)1.0 (reference)759 (1.3)1.0 (reference)742 (1.2)1.0 (reference)
Term pre-eclampsia21 95037 (1.7)1.7 (1.2 to 2.4)32 (1.5)1.4 (0.95 to 1.91)30 (1.3)1.3 (0.89 to 1.8)
Preterm pre-eclampsia446012 (2.7)3.7 (2.1 to 6.6)4 (0.90)1.12 (0.42 to 3.0)7 (1.6)1.9 (0.91 to 4.0)

*ICD-10 codes. ICD-10 covered the years 1996-2009, ICD-8 and ICD-9 covered years 1967-95 (see Methods).

†Adjusted for maternal education (three categories), maternal age at first birth, and year of first birth.