Long term mortality from circulatory causes in women with pre-eclampsia during first singleton pregnancy
| Outcome of first pregnancy | No of women | Ischaemic heart disease (codes I20-I25)* | Cerebrovascular disease (stroke, codes I60-I69)* | All other circulatory causes | |||||
|---|---|---|---|---|---|---|---|---|---|
| No of deaths (per 1000) | Adjusted hazard ratio (95% CI)† | No of deaths (per 1000) | Adjusted hazard ratio (95% CI)† | No of deaths (per 1000) | Adjusted hazard ratio (95% CI)† | ||||
| Women with one lifetime pregnancy | |||||||||
| No pre-eclampsia, term birth | 112 208 | 313 (2.8) | 2.0 (1.8 to 2.4) | 294 (2.6) | 1.9 (1.6 to 2.2) | 332 (3.0) | 2.0 (1.8 to 2.4) | ||
| Term pre-eclampsia | 4758 | 34 (7.1) | 4.7 (3.3 to 6.7) | 14 (2.9) | 2.1 (1.2 to 3.6) | 17 (3.6) | 2.4 (1.5 to 3.9) | ||
| Preterm pre-eclampsia | 1426 | 15 (10.5) | 9.3 (5.5 to 15.6) | 16 (11.2) | 10.4 (6.3 to 17.2) | 6 (4.2) | 3.6 (1.6 to 8.0) | ||
| Women with two or more lifetime pregnancies | |||||||||
| No pre-eclampsia, term birth | 599 973 | 675 (1.1) | 1.0 (reference) | 759 (1.3) | 1.0 (reference) | 742 (1.2) | 1.0 (reference) | ||
| Term pre-eclampsia | 21 950 | 37 (1.7) | 1.7 (1.2 to 2.4) | 32 (1.5) | 1.4 (0.95 to 1.91) | 30 (1.3) | 1.3 (0.89 to 1.8) | ||
| Preterm pre-eclampsia | 4460 | 12 (2.7) | 3.7 (2.1 to 6.6) | 4 (0.90) | 1.12 (0.42 to 3.0) | 7 (1.6) | 1.9 (0.91 to 4.0) | ||
*ICD-10 codes. ICD-10 covered the years 1996-2009, ICD-8 and ICD-9 covered years 1967-95 (see Methods).
†Adjusted for maternal education (three categories), maternal age at first birth, and year of first birth.