Long term mortality from cardiovascular* and other causes in women with pre-eclampsia during first singleton pregnancy
| Outcome of first pregnancy | No of women | All deaths | Cardiovascular deaths | Non-cardiovascular deaths† | |||||
|---|---|---|---|---|---|---|---|---|---|
| No of deaths (per 1000) | Adjusted hazard ratio (95% CI)‡ | No of deaths (per 1000) | Adjusted hazard ratio (95% CI)‡ | No of deaths (per 1000) | Adjusted hazard ratio (95% CI)‡ | ||||
| All women | |||||||||
| No pre-eclampsia | 801 323 | 22 107 (27.6) | 1.0 (reference) | 2380 (3.0) | 1.0 (reference) | 18 456 (23.0) | 1.0 (reference) | ||
| All pre-eclampsia | 34 824 | 902 (25.9) | 1.1 (1.0 to 1.1) | 176 (5.1) | 1.9 (1.6 to 2.2) | 660 (19.0) | 0.93 (0.86 to 1.00) | ||
| No pre-eclampsia, term birth | 712 181 | 19 214 (27.0) | 1.0 (reference) | 2011 (2.8) | 1.0 (reference) | 16 129 (22.6) | 1.0 (reference) | ||
| Term pre-eclampsia | 26 708 | 674 (25.2) | 1.0 (0.94 to 1.1) | 115 (4.3) | 1.6 (1.4 to 2.0) | 512 (19.2) | 0.92 (0.85 to 1.01) | ||
| Preterm pre-eclampsia | 5886 | 169 (28.7) | 1.4 (1.2 to 1.6) | 45 (7.6) | 3.7 (2.7 to 4.8) | 111 (18.9) | 1.08 (0.89 to 1.31) | ||
| Women with one lifetime pregnancy | |||||||||
| No pre-eclampsia, term birth | 112 208 | 5311 (47.3) | 1.9 (1.8 to 1.9) | 596 (5.3) | 2.0 (1.8 to 2.2) | 4382 (39.1) | 1.8 (1.8 to 1.9) | ||
| Term pre-eclampsia | 4758 | 227(47.7) | 1.8 (1.6 to 2.1) | 47 (9.9) | 3.4 (2.6 to 4.6) | 163 (34.3) | 1.6 (1.4 to 1.9) | ||
| Preterm pre-eclampsia | 1426 | 92 (64.5) | 3.1 (2.5 to 3.9) | 29 (20.3) | 9.4 (6.5 to 13.7) | 57 (40.0) | 2.3 (1.7 to 3.0) | ||
| Women with two or more lifetime pregnancies | |||||||||
| No pre-eclampsia, term birth | 599 973 | 13 903 (23.2) | 1.0 (reference) | 1415 (2.4) | 1.0 (reference) | 11 746 (19.6) | 1.0 (reference) | ||
| Term pre-eclampsia | 21 950 | 447 (20.4) | 1.0 (0.90 to 1.1) | 68 (3.1) | 1.5 (1.2 to 2.0) | 349 (15.9) | 0.93 (0.84 to 1.04) | ||
| Preterm pre-eclampsia | 4460 | 77 (17.3) | 1.1 (0.87 to 1.4) | 16 (3.6) | 2.4 (1.5 to 3.9) | 54 (12.1) | 0.89 (0.68 to 1.2) | ||
*Ischaemic heart disease and stroke combined, excluding other circulatory conditions (see table 2).
†Excluding all circulatory conditions.
‡Adjusted for maternal education (three categories), maternal age at first birth, and year of first birth.