Secondary outcomes
| Outcome* | Events (studies) | Event risk† | Random effects risk ratio (95% CI) | Fixed effects risk ratio (95% CI) | I2 |
|---|---|---|---|---|---|
| Cardiovascular events | 1423 (5) | 6.4% | 1.24 (0.81 to 1.89) | 1.30 (1.13 to 1.50) | 85% |
| Coronary mortality | 3166 (9) | 1.8% | 1.08 (0.97 to 1.21) | 1.07 (0.99 to 1.17) | 29% |
| Cerebrovascular mortality | 2738 (4) | 1.0% | 1.12 (0.89 to 1.40) | 1.12 (0.99 to 1.28) | 52% |
| Cardiovascular mortality | 17 335 (5) | 1.2% | 1.14 (0.98 to 1.32) | 1.04 (0.99 to 1.09) | 65% |
| All cause mortality | 8092 (8) | 8.0% | 1.04 (0.97 to 1.11) | 1.03 (0.98 to 1.09) | 36% |
*See web extra table A for study level definitions.
†Random effects mean event risk totalled over follow-up for cohort studies.