Baseline characteristics of women in derivation and validation cohorts used to determine algorithm for identification of those with ovarian cancer. Patients were free from diagnosis of ovarian cancer at baseline. Figures are numbers (percentages) unless otherwise specified
| Derivation cohort (n=1 158 723) | Validation cohort (n=608 862) | |
|---|---|---|
| Mean (SD) age (years) | 51 (15.5) | 50.9 (15.4) |
| Mean (SD) Townsend score (deprivation) | −0.4 (3.3) | −0.2 (3.5) |
| BMI recorded before study entry | 956 594 (82.6) | 512 388 (84.2) |
| Mean (SD) BMI | 26.1 (5.0) | 26.2 (5.0) |
| Smoking status: | ||
| Non-smoker | 666 968 (57.6) | 348 702 (57.3) |
| Ex-smoker | 190 871 (16.5) | 102 369 (16.8) |
| Current smoker (number not recorded) | 25 634 (2.2) | 14 067 (2.3) |
| Light smoker (<10/day) | 63 092 (5.4) | 33 721 (5.5) |
| Moderate smoker (10-19/day) | 88 433 (7.6) | 47 486 (7.8) |
| Heavy smoker (≥20 day) | 53 408 (4.6) | 29 228 (4.8) |
| Not recorded | 70 317 (6.1) | 33 289 (5.5) |
| Alcohol status: | ||
| None | 329 078 (28.4) | 176 830 (29.0) |
| Trivial (<1 unit/day) | 381 599 (32.9) | 207 388 (34.1) |
| Light (1-2 units/day) | 196 164 (16.9) | 100 966 (16.6) |
| Moderate or heavy (≥3 units/day) | 28 396 (2.5) | 14 740 (2.4) |
| Not recorded | 223 486 (19.3) | 108 938 (17.9) |
| Medical history: | ||
| Previous cancer apart from ovarian cancer | 29 333 (2.5) | 15 404 (2.5) |
| Family history of ovarian cancer | 1991 (0.2) | 1297 (0.2) |
| Current symptoms: | ||
| Abdominal pain | 132 576 (11.4) | 73 674 (12.1) |
| Abdominal distension | 5140 (0.4) | 3185 (0.5) |
| Appetite loss | 5920 (0.5) | 3176 (0.5) |
| Rectal bleeding | 25 274 (2.2) | 13 988 (2.3) |
| Postmenopausal bleeding | 18 244 (1.6) | 10 285 (1.7) |
| Weight loss | 13 858 (1.2) | 7725 (1.3) |
| Symptoms in preceding year: | ||
| Constipation | 9081 (0.8) | 5138 (0.8) |
| Diarrhoea | 12 259 (1.1) | 6858 (1.1) |
| Tiredness | 15 265 (1.3) | 8608 (1.4) |
| Urinary frequency | 931 (0.1) | 745 (0.1) |
| Haemoglobin recorded | 242 535 (20.9) | 130 067 (21.4) |
| Haemoglobin <110 g/L | 23 589 (2.0) | 12 894 (2.1) |