Differences in primary outcomes between discontinuation and continuation study groups, after 25 weeks
| Primary outcome | Regression coefficient* | Standard error | P | 95% CI |
|---|---|---|---|---|
| Cornell scale | ||||
| Total score | −2.89 | 0.94 | 0.003† | −4.76 to −1.02 |
| Total score (baseline score <9) | −3.36 | 0.94 | 0.001† | −5.23 to −1.48 |
| Total score (baseline score ≥9) | 2.20 | 1.86 | 0.251 | −1.68 to 6.09 |
| Mood score | −0.73 | 0.37 | 0.054 | −1.47 to 0.01 |
| Non-mood score | −1.89 | 0.85 | 0.028† | −3.56 to −0.21 |
| Neuropsychiatric inventory | ||||
| Total score | −5.96 | 3.23 | 0.068 | −12.35 to 0.44 |
| Affective subsyndrome | −2.25 | 1.00 | 0.027† | −4.24 to −0.27 |
| Agitation subsyndrome | −1.14 | 1.40 | 0.417 | −3.93 to 1.64 |
| Psychosis subsyndrome | −0.56 | 0.89 | 0.527 | −2.32 to 1.19 |
| Apathy | −0.48 | 0.72 | 0.507 | −1.90 to 0.94 |
Data calculated by linear multi level model analysis.
*Negative score indicates higher score on Cornell scale and neuropsychiatric inventory in the discontinuation group.
†P<0.05.