Hazard ratios for hospital admission and death due to thromboembolism* by combinations of covariates composing CHADS2 scores 1 and 2
| Score and covariates | 1 year’s follow-up | 5 years’ follow-up | 10 years’ follow-up | |||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |||
| CHADS2 score=0 | 1.00 | 1.00 | 1.00 | |||||
| CHADS2 score=1: | ||||||||
| Heart failure | 1.67 (1.06 to 2.63) | 0.03 | 1.99 (1.53 to 2.58) | <0.0001 | 1.84 (1.43 to 2.35) | <0.0001 | ||
| Hypertension | 1.45 (1.17 to 1.79) | 0.0006 | 1.52 (1.34 to 1.73) | <0.0001 | 1.56 (1.39 to 1.74) | <0.0001 | ||
| Age≥75 | 3.52 (3.05 to 4.07) | <0.0001 | 3.62 (3.31 to 3.96) | <0.0001 | 3.59 (3.31 to 3.90) | <0.0001 | ||
| Diabetes mellitus | 1.79 (1.16 to 2.77) | 0.009 | 1.84 (1.41 to 2.39) | <0.0001 | 1.93 (1.53 to 2.45) | <0.0001 | ||
| CHADS2 score=2: | ||||||||
| Diabetes + heart failure | 3.74 (1.93 to 7.28) | 0.0001 | 4.75 (3.21 to 7.03) | <0.0001 | 4.52 (3.10 to 6.59) | <0.0001 | ||
| Diabetes + hypertension | 1.67 (1.05 to 2.67) | 0.03 | 2.11 (1.62 to 2.74) | <0.0001 | 2.17 (1.71 to 2.76) | <0.0001 | ||
| Diabetes + age≥75 | 4.57 (3.47 to 6.02) | <0.0001 | 4.16 (3.44 to 5.04) | <0.0001 | 3.98 (3.31 to 4.79) | <0.0001 | ||
| Heart failure + hypertension | 2.63 (1.87 to 3.70) | <0.0001 | 2.61 (2.09 to 3.24) | <0.0001 | 2.55 (2.08 to 3.12) | <0.0001 | ||
| Heart failure + age≥75 | 3.84 (3.19 to 4.64) | <0.0001 | 4.04 (3.58 to 4.56) | <0.0001 | 4.04 (3.61 to 4.53) | <0.0001 | ||
| Hypertension + age≥75 | 4.08 (3.48 to 4.77) | <0.0001 | 4.22 (3.83 to 4.66) | <0.0001 | 4.14 (3.78 to 4.53) | <0.0001 | ||
| Previous thromboembolism | 9.13 (7.55 to 11.04) | <0.0001 | 6.30 (5.52 to 7.19) | <0.0001 | 6.05 (5.35 to 6.83) | <0.0001 | ||
Results from Cox proportional hazard analyses; CHADS2 score=0 was reference.
*Includes peripheral artery embolism, ischaemic stroke, and pulmonary embolism.