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Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care

BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7498.1003 (Published 28 April 2005) Cite this as: BMJ 2005;330:1003

Data supplement


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    Summary of previous trials of calcium and cholecalciferol (vitamin D3)

    Study

    Population and setting

    Summary of results

    Calcium and vitamin D:

    		  

    Nursing home:

    		  

    Chapuy et al, 1992

    2790 women (mean age 84) in French nursing homes

    Significant reduction in all fractures (odds ratio 0.72, 95% confidence interval 0.57 to 0.90)

    Chapuy et al, 2002

    583 women (mean age 85) in French nursing homes

    No reduction in all fractures (odds ratio 0.99, 95% confidence interval 0.62 to 1.62)

    Community:

    		  

    Dawson-Hughes, 1997

    389 community dwelling men and women (>65) in USA

    Significant reduction in osteoporotic fractures (odds ratio 0.42, 95% confidence interval 0.18 to 0.92)

    Larsen et al, 2004

    9605 community dwelling men and women in Denmark

    16% reduction in fracture incidence

    Calcium with or without vitamin D:

    		  

    Medical Research Council RECORD trial, 2005

    5292 men and women (aged over 70), recruited from fracture clinics in UK to a factorial trial comparing calcium with or without cholecalciferol

    No difference in fracture incidence (hazard ratio 0.94, 95% confidence interval 0.81 to 1.09 for calcium v no calcium, and 1.02, 95% confidence interval 0.88 to 1.19 for vitamin D v no vitamin D)

    Vitamin D alone:

    		  

    Lips et al, 1996

    2578 men and women (aged over 70) randomised to 400 IU of vitamin D daily

    Slight increase in risk of hip fracture among participants allocated to vitamin D (hazard ratio 1.18, 95% confidence interval 0.81 to 1.71)

    Trivedi et al, 2003

    2686 mainly retired male doctors allocated to 100 000 IU of vitamin D every four months

    Slight decrease in relative risk of fracture (0.78, 95% confidence interval 0.61 to 0.99)

    Smith et al, 2004

    9440 men and women (aged 75 and over) allocated to annual injection of 300 000 IU of vitamin D

    Slight increase in risk of all fractures and large increase in hip fractures (hazard ratio 1.10, 95% confidence interval 0.94 to 1.29 for all fractures and 1.48, 95% confidence interval 1.01 to 2.17 for hip fractures)

     

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