Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care
BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7498.1003 (Published 28 April 2005) Cite this as: BMJ 2005;330:1003Data supplement
Summary of previous trials of calcium and cholecalciferol (vitamin D3)
Study
Population and setting
Summary of results
Calcium and vitamin D:
Nursing home:
Chapuy et al, 1992
2790 women (mean age 84) in French nursing homes
Significant reduction in all fractures (odds ratio 0.72, 95% confidence interval 0.57 to 0.90)
Chapuy et al, 2002
583 women (mean age 85) in French nursing homes
No reduction in all fractures (odds ratio 0.99, 95% confidence interval 0.62 to 1.62)
Community:
Dawson-Hughes, 1997
389 community dwelling men and women (>65) in USA
Significant reduction in osteoporotic fractures (odds ratio 0.42, 95% confidence interval 0.18 to 0.92)
Larsen et al, 2004
9605 community dwelling men and women in Denmark
16% reduction in fracture incidence
Calcium with or without vitamin D:
Medical Research Council RECORD trial, 2005
5292 men and women (aged over 70), recruited from fracture clinics in UK to a factorial trial comparing calcium with or without cholecalciferol
No difference in fracture incidence (hazard ratio 0.94, 95% confidence interval 0.81 to 1.09 for calcium v no calcium, and 1.02, 95% confidence interval 0.88 to 1.19 for vitamin D v no vitamin D)
Vitamin D alone:
Lips et al, 1996
2578 men and women (aged over 70) randomised to 400 IU of vitamin D daily
Slight increase in risk of hip fracture among participants allocated to vitamin D (hazard ratio 1.18, 95% confidence interval 0.81 to 1.71)
Trivedi et al, 2003
2686 mainly retired male doctors allocated to 100 000 IU of vitamin D every four months
Slight decrease in relative risk of fracture (0.78, 95% confidence interval 0.61 to 0.99)
Smith et al, 2004
9440 men and women (aged 75 and over) allocated to annual injection of 300 000 IU of vitamin D
Slight increase in risk of all fractures and large increase in hip fractures (hazard ratio 1.10, 95% confidence interval 0.94 to 1.29 for all fractures and 1.48, 95% confidence interval 1.01 to 2.17 for hip fractures)
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- Introductory AddressProv Med Surg J October 03, 1840, s1-1 (1) 1-4; DOI: https://doi.org/10.1136/bmj.s1-1.1.1
- Report of the Meeting of the Eastern Branch of the Provincial Association at Bury St. Edmond'sProv Med Surg J October 03, 1840, s1-1 (1) 10-13; DOI: https://doi.org/10.1136/bmj.s1-1.1.10
- Mr. Warburton's Bill for the Regulation of the Medical ProfessionProv Med Surg J October 03, 1840, s1-1 (1) 13-15; DOI: https://doi.org/10.1136/bmj.s1-1.1.13
- An Atlas of Plates, illustrative of the Principles and Practice of Obstetric Medicine and Surgery, with descriptive LetterpressProv Med Surg J October 03, 1840, s1-1 (1) 4; DOI: https://doi.org/10.1136/bmj.s1-1.1.4
- A Practical Treatise on the Diseases peculiar to Women, illustrated by Cases, &cProv Med Surg J October 03, 1840, s1-1 (1) 4-5; DOI: https://doi.org/10.1136/bmj.s1-1.1.4-a
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