Treating behavioural and psychological signs in Alzheimer's disease
BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7203.138 (Published 17 July 1999) Cite this as: BMJ 1999;319:138
Data supplement
Double blind placebo controlled randomised trials of neuroleptics for behavioural and psychological signs in dementia
Study and year
Active agent
Duration (weeks)
Sample size
Mean age (years)
Mean outcome assessment
% Significantly improved
Comments
1960(1)
Chlorpromazine
8
32
75
Clinical observation
NS
Proportions not specified
1962(2)
Trifluoperazine
8
27
71
Behavioural assessment scale
22 v 0
All medically unwell
1962(3)
Acetophonazine
8
19
71
Clinical observation
64 v 20
1964(4)
Haloperidol
6
18
71
Unvalidated checklist
89 v 67
1973(5)
Penfluridol
36
81
Beoordingsschaal Oudere Pattienten
NS
Portions not specified
1976(6)
Thiothixene
42
76
Brief psychiatric rating scale
59 v 55
1982(7)
Haloperidol loxepine
8
61
73
Brief psychiatric rating scale
65 v 58 v 36
1982(8)
Thioridozine loxepine
8
53
83
Brief psychiatric rating scale
59 v 68 v 47
1995(9)
Thiothixene
11
33
85
Cohen-Mansfield agitation inventory
65 v 19
1998(10)
Risperidone haloperidol
12
344
81
Behav-AD
76 v 69 v 61
1999(11)
Risperidone
12
435
83
Behav-AD
68 v 61
Overall difference significant only for 2 mg/day
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- Hamilton LD, Bennett JL. The use of trifluoperazine in geriatric patients with chronic brain syndrome. J Am Geriatr Soc 1962;10:140-7.
- Hamilton LD, Bennett JL. Acetophenazine for hyperactive geriatric patients. Geratrics 1962;17:596-601.
- Sugarmann AA, Williams BH, Alderstein AM. Haloperidol in the psychiatric disorders of old age. Am J Psych 1964;120:1190-2.
- Cahn LA, Diesfeldt HFA. The use of neuroleptics in the treatment of dementia in old age. Psych Neurol Neuochir 1973;76:411-20.
- Rada RT, Kellner R. Thiothixene in the treatment of geriatric patients with chronic organic brain syndrome. J Am Geriatr Soc 1976;3:105-7.
- Petrie WM, Ban TA, Berney S. Loxepine in psychogeriatrics: a placebo and standard controlled clinical investigation. J Clin Psychopharmacol 1982;2:122-6.
- Barnes R, Veith R, Okimoto J. Efficacy of antipsychotic medications in behaviourally disturbed dementia patients. Am J Psych 1982;139:1170-4.
- Finkel SI. Lyons JS, Anderson RL, Sherell J, Davis J. A randomised placebo controlled trial of thiothixene in agitated demented nursing home patients. Int J Ger Psych 1995;10:129-36.
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- Katz IR, Joste DV, Mintzer JE, Clyde C, Napolitano J, Brecher M. Comparison of risperidone and placebo for psychological and behavioural disturbances associated with dementia: a randomised double blind trial. J Clin Psych 1999;60:107-15.
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