Research Article

Local infusion of urokinase and heparin into renal arteries in impending renal cortical necrosis.

Br Med J 1975; 4 doi: (Published 06 December 1975) Cite this as: Br Med J 1975;4:547
  1. F E Jones,
  2. P J Black,
  3. J S Cameron,
  4. C Chantler,
  5. D Gill,
  6. M N Maisey,
  7. C S Ogg,
  8. H Saxton


    Two patients with presumed impending cortical necrosis, after haemolytic uraemic syndrome in one and after concealed accidental haemorrhage in the other, were treated by local infusion of urokinase and heparin into the renal artery. Both recovered and one regained normal renal function. Local infusion of anticoagulants or thrombolytic drugs into one renal artery offers the possibility of a controlled examination of the efficacy of this treatment in preventing cortical necrosis.