H-rosette formation in T-cell-proliferative diseases.Br Med J 1975; 4 doi: https://doi.org/10.1136/bmj.4.5993.381 (Published 15 November 1975) Cite this as: Br Med J 1975;4:381
- P J Sheldon,
- E J Holborow
In health up to 6% of human lymphocytes will form rosettes with homologous group O rhesus-negative erythrocytes (H rosettes). Increased numbers of H rosettes were found in T-cell-proliferative diseases-- namely, infectious mononucleosis, Sézary's syndrome, and T-cell leukaemia. H-rosette formation is thus a marker for a subpopulation of T lymphocytes, and this easily performed test of T-cell activation may have clinical value in characterising changes in blood lymphocyte populations in disease.