Neonatal Hyperthyroidism and Long-acting Thyroid Stimulator ProtectorBr Med J 1974; 4 doi: https://doi.org/10.1136/bmj.4.5946.695 (Published 21 December 1974) Cite this as: Br Med J 1974;4:695
- J. Nutt,
- F. Clark,
- R. G. Welch,
- R. Hall
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may have been the cause of the neonatal hyperthyroidism.