Papers And Originals

Pruritic Effect of Bile Salts

Br Med J 1974; 4 doi: http://dx.doi.org/10.1136/bmj.4.5946.693 (Published 21 December 1974) Cite this as: Br Med J 1974;4:693
  1. J. Kirby,
  2. K. W. Heaton,
  3. J. L. Burton

    Abstract

    The pruritic effect of purified bile salts has been tested by applying them to blister bases. All the salts tested were pruritogens, but the dihydroxy salts (especially unconjugated chenodeoxycholate) were more effective than the trihydroxy salts. This may explain the poor correlation between total serum bile salt concentration and pruritus in obstructive jaundice.