Papers And Originals

Cell-mediated Immunity to Intrinsic Factor in Autoimmune Disorders

Br Med J 1974; 4 doi: (Published 30 November 1974) Cite this as: Br Med J 1974;4:494
  1. D. James,
  2. G. Asherson,
  3. I. Chanarin,
  4. N. Coghill,
  5. S. Hamilton,
  6. R. L. Himsworth,
  7. D. Webster


    Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.