Papers And Originals

Safe Method of Collecting Leukaemia Cells from Patients with Acute Leukaemia for Use as Immunotherapy

Br Med J 1974; 4 doi: https://doi.org/10.1136/bmj.4.5941.375 (Published 16 November 1974) Cite this as: Br Med J 1974;4:375
  1. R. L. Powles,
  2. T. A. Lister,
  3. R. T. D. Oliver,
  4. J. Russell,
  5. C. Smith,
  6. H. E. M. Kay,
  7. T. J. McElwain,
  8. G. Hamilton Fairley

    Abstract

    Leukaemia cells were collected from the blood of 72 untreated patients using a continuous-flow blood cell separator. The yield of cells was proportional to the number circulating in the patient, and up to 1 × 1012 could be obtained in three hours. Complications of the procedure were mild, consisting of chills and shivering in 18% of patients. Leucopheresis at the time of diagnosis is an essential part of setting up a specific immunotherapy programme for patients with acute myelogenous leukaemia, and the lack of harmful side effects makes the collection of these cells ethically justified. The need for a centralized service to provide cells for this form of therapy is emphasized.