Combined T and B Cell Acute Lymphoblastic LeukaemiaBr Med J 1974; 4 doi: https://doi.org/10.1136/bmj.4.5936.79 (Published 12 October 1974) Cite this as: Br Med J 1974;4:79
- D. G. Haegert,
- J. C. Cawley,
- A. Karpas,
- A. H. Goldstone
A case of acute lymphoblastic leukaemia in a 17-year-old male is described. The patient had many distinctive features including a very high blast cell count, prominent lymphadenopathy and hepatosplenomegaly, thymic mass, and a fulminant clinical course. Immunological studies on the blast cells using a variety of techniques showed the presence of two distinct subpopulations, one having the surface characteristics of thymus-dependent (T) lymphoid cells and the other those of bursa-equivalent (B) lymphoid cells. The case therefore represents the first example of a combined T and B cell acute leukaemia.