Papers And Originals

Organ-specific Antibodies in Patients with Lichen Sclerosus

Br Med J 1974; 4 doi: (Published 12 October 1974) Cite this as: Br Med J 1974;4:78
  1. S. K. Goolamali,
  2. E. W. Barnes,
  3. W. J. Irvine,
  4. Sam Shuster


    Organ-specific antibodies were looked for in 26 patients with lichen sclerosus. Ten of the 25 female patients (40%) had organ-specific antibodies to thyroid cytoplasm and 11 (44%) had organ-specific antibodies to gastric parietal cells. Both values were significantly greater than those obtained in age-matched controls. None of the sera from patients with lichen sclerosus contained antibodies to steroid-producing tissues. No organ-specific antibodies were found in the one male patient.

    The findings suggest that lichen sclerosus may be related to an autoimmune process.