Papers And Originals

Chronic Liver Disease: Differences in Autoimmune Serological Reactions between Australians and Asians

Br Med J 1973; 4 doi: (Published 01 December 1973) Cite this as: Br Med J 1973;4:517
  1. Senga Whittingham,
  2. Ian R. Mackay,
  3. R. S. Thanabalasundrum,
  4. H. K. Chuttani,
  5. R. Manjuran,
  6. C. S. Seah,
  7. M. Yu,
  8. V. Viranuvatti


    A total of 164 patients from Australia, Ceylon, India, Singapore, and Thailand were studied for the prevalence of autoantibodies associated with “idiopathic” chronic liver disease—namely, antinuclear antibody, smooth muscle antibody, and mitochondrial antibody. The prevalence of these autoantibodies was high among patients from Australia (55%), but was low among patients from Ceylon (14%), India (11%), Singapore (0%), and Thailand (8%). There are variations in types of hepatitis and cirrhosis between races, and this applies particularly to the type associated with autoimmune markers. This may be related to genetic differences that have evolved between peoples of European and Asian descent.