Use of 5-Fluorocytosine in Patients with Impaired Renal FunctionBr Med J 1973; 4 doi: http://dx.doi.org/10.1136/bmj.4.5889.382 (Published 17 November 1973) Cite this as: Br Med J 1973;4:382
- J. K. Dawborn,
- M. D. Page,
- D. J. Schiavone
The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.