Rapid Microbiological Assay for 5-FluorocytosineBr Med J 1973; 4 doi: https://doi.org/10.1136/bmj.4.5889.380 (Published 17 November 1973) Cite this as: Br Med J 1973;4:380
- D. J. Schiavone,
- M. D. Page,
- J. K. Dawborn
A microbiological assay was developed for 5-fluorocytosine based on inhibition by the drug of the fall in pH produced by Candida albicans in a synthetic liquid culture medium. Serum and urine levels of the drug could be measured reproducibly in four hours.