Benign Obstetric History in Women with Sickle-cell Anaemia Associated with α-ThalassaemiaBr Med J 1972; 4 doi: http://dx.doi.org/10.1136/bmj.4.5839.524 (Published 02 December 1972) Cite this as: Br Med J 1972;4:524
- A. van Enk,
- A. Lang,
- J. M. White,
- H. Lehmann
Two Ghanaian women with sickle-cell anaemia and α-thalassaemia were found to have an unusually benign obstetric history. In addition to two factors present which are known to moderate the clinical course of sickle-cell anaemia, good socioeconomic status and a relatively high Hb F level, it is suggested that α-thalassaemia may act among other things by lowering the haemoglobin concentration in the red cells and thereby lowering their tendency to sickle in vivo.