Induction of Labour by Simultaneous Intravenous Administration of Prostaglandin E2 and OxytocinBr Med J 1972; 4 doi: https://doi.org/10.1136/bmj.4.5838.461 (Published 25 November 1972) Cite this as: Br Med J 1972;4:461
- William C. M. K. Naismith,
- Wallace Barr,
- J. MacVicar
In a group of 20 matched primigravid patients labour was induced by forewater amniotomy followed by intravenous oxytocin (Syntocinon) administered in escalating doses. Ten of these patients, in a double-blind trial, also received prostaglandin E2 infused simultaneously with the oxytocin. In the combined prostaglandin-oxytocin group there was a noticeable reduction in the dosage of oxytocin required to produce effective uterine action, and the duration of labour was also reduced. No side effects were observed.