Papers And Originals

Origin of Endothelium in Human Renal Allografts

Br Med J 1972; 4 doi: https://doi.org/10.1136/bmj.4.5831.15 (Published 07 October 1972) Cite this as: Br Med J 1972;4:15
  1. R. A. Sinclair

    Abstract

    Sex chromatin counts performed on the endothelial cells of 40 human kidneys transplanted to recipients of the opposite sex showed that the donor endothelium had persisted except in three poorly functioning and severely damaged grafts. In these a high proportion of the endothelial cells in peritubular capillaries and veins were derived from the host. Endothelial repopulation of organ allografts probably occurs only after severe tissue injury, and it cannot explain the phenomenon of graft adaptation. Repopulated endothelium may be derived from circulating cells.