Papers And Originals

Specific Immune Response in Human Skin Carcinoma

Br Med J 1971; 4 doi: https://doi.org/10.1136/bmj.4.5789.701 (Published 18 December 1971) Cite this as: Br Med J 1971;4:701
  1. R. C. Nairn,
  2. A. P. P. Nind,
  3. E. P. G. Guli,
  4. H. K. Muller,
  5. J. M. Rolland,
  6. C. C. J. Minty

    Abstract

    Eight out of nine patients with squamous cell carcinoma of skin have shown immunological reactivity against their own tumour cells by one or more tests with their sera or peripheral blood lymphocytes. The tests included membrane and cytoplasmic immunofluorescence, and, with cultured tumour, complement-dependent serum cytotoxicity and lymphocyte attack. One case examined in depth had an unusually conspicuous lymphocyte and plasma cell reaction on histological examination, and was positive by all four tests; a time-lapse cinephoto-micrographic record over seven days was obtained of the attack on the carcinoma cells in culture by the patient's lymphocytes.