Endogenous Creatinine Clearance as a Clinical Measure of Glomerular Filtration RateBr Med J 1971; 4 doi: https://doi.org/10.1136/bmj.4.5779.84 (Published 09 October 1971) Cite this as: Br Med J 1971;4:84
- William M. Bennett,
- George A. Porter
Endogenous creatinine clearance was assessed by inulin in 91 simultaneous studies in 41 patients and proved an accurate measurement of glomerular filtration rate. For filtration rates <20 ml/min the creatinine clearance may slightly overestimate the glomerular filtration rate. Successive determinations of filtration rate by either method may vary by 20% even though the methods agree with each other. Glomerular filtration rate itself is variable, and in its clinical usage this should be recognized.
↵* Supported by PHS-CV Program Project HE 06336-10 CRC 5 MOI RR 334-05.