Papers And Originals

Endogenous Creatinine Clearance as a Clinical Measure of Glomerular Filtration Rate

Br Med J 1971; 4 doi: https://doi.org/10.1136/bmj.4.5779.84 (Published 09 October 1971) Cite this as: Br Med J 1971;4:84
  1. William M. Bennett,
  2. George A. Porter

    Abstract

    Endogenous creatinine clearance was assessed by inulin in 91 simultaneous studies in 41 patients and proved an accurate measurement of glomerular filtration rate. For filtration rates <20 ml/min the creatinine clearance may slightly overestimate the glomerular filtration rate. Successive determinations of filtration rate by either method may vary by 20% even though the methods agree with each other. Glomerular filtration rate itself is variable, and in its clinical usage this should be recognized.

    Footnotes

    • * Supported by PHS-CV Program Project HE 06336-10 CRC 5 MOI RR 334-05.