Baclofen in the Treatment of SpasticityBr Med J 1971; 4 doi: https://doi.org/10.1136/bmj.4.5778.15 (Published 02 October 1971) Cite this as: Br Med J 1971;4:15
- P. Hudgson,
- D. Weightman
Baclofen† (Lioresal), a derivative of gamma-aminobutyric acid, was introduced in 1966 as a possible treatment for spasticity due to corticospinal tract lesions. Preliminary studies suggested that it may be more effective than other spasmolytic agents currently available, and a double-blind controlled trial in a group of 23 patients against placebo has shown it to be significantly more effective.
↵* An abbreviated version of this paper was read at an International Symposium on Current Aspects of Muscle Spasticity, Vienna, April 1971.