Papers And Originals

Treatment of Zoster with Idoxuridine in Dimethyl Sulphoxide. Results of Two Double-blind Controlled Trials

Br Med J 1970; 4 doi: https://doi.org/10.1136/bmj.4.5738.776 (Published 26 December 1970) Cite this as: Br Med J 1970;4:776

This article has a correction. Please see:

  1. B. E. Juel-Jensen,
  2. F. O. MacCallum,
  3. A. M. R. Mackenzie,
  4. M. C. Pike

    Abstract

    The antiviral effect of 5% idoxuridine in dimethyl sulphoxide intermittently applied and of 40% idoxuridine in dimethyl sulphoxide continuously applied for four days to the lesions in patients with zoster of recent onset was studied in two double-blind controlled trials. Most, but not all, of the patients receiving intermittent active treatment had pain for a short period only. The effect of continuous treatment was striking: pain had disappeared within nine days in all the patients and healing was accelerated. The results were statistically significant.