Papers And Originals

Single-dose Therapy with Streptomycin and Sulfametopyrazine for Bacteriuria during Pregnancy

Br Med J 1970; 4 doi: (Published 12 December 1970) Cite this as: Br Med J 1970;4:651
  1. J. D. Williams,
  2. Edna K. Smith


    One hundred and sixty-three patients with bacteriuria in pregnancy were treated with a single dose of antibiotic. Four regimens were used: sulfadoxine (sulphormethoxine) 2 g., sulfametopyrazine 2 g., streptomycin 1 g., and a combination of sulfametopyrazine 2 g. and streptomycin 1 g. The highest cure rate of 77% was achieved with streptomycin and sulfametopyrazine. The long-acting sulphonamides alone gave a cure rate of 55% while streptomycin alone eradicated 43% of the infections. Despite the high cure rate with combined therapy bacterial resistance developed in some cases.