Papers And Originals

Effects of Isoprenaline Plus Phenylephrine by Pressurized Aerosol on Blood Gases, Ventilation, and Perfusion in Chronic Obstructive Lung Disease

Br Med J 1970; 4 doi: (Published 05 December 1970) Cite this as: Br Med J 1970;4:579
  1. L. H. Harris


    The effects of a combined isoprenaline-phenylephrine inhalant in chronic obstructive lung disease were assessed in 23 patients. Significant changes occurred in blood gas tensions after inhalation, together with an overall improvement in ventilation/perfusion ratios. Cardiac output and physiological shunt were not significantly increased. Hence the addition of phenylephrine probably prevents the increase of hypoxaemia which may result from the disproportionate ventilation/perfusion ratio produced by sympathomimetics or xanthines used alone. The combination aerosol has a satisfactory bronchodilator effect, and is additionally safe if used by a severely hypoxic patient unaware of the seriousness of his condition.