Preliminary Communications

Endotoxin and Acute Renal Failure Associated with Obstructive Jaundice

Br Med J 1970; 4 doi: https://doi.org/10.1136/bmj.4.5733.472 (Published 21 November 1970) Cite this as: Br Med J 1970;4:472
  1. E. N. Wardle,
  2. N. A. Wright

    Abstract

    A single dose of endotoxin given to rats with obstructive jaundice produced death with intravascular coagulation. This action was apparently due to delayed clearance of endotoxin from the circulation. The finding is relevant to “hepatorenal failure,” which can be caused by bacteraemia after biliary tract operations.

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