Papers And Originals

Secretory IgA in Urinary Tract Infections

Br Med J 1970; 4 doi: http://dx.doi.org/10.1136/bmj.4.5733.463 (Published 21 November 1970) Cite this as: Br Med J 1970;4:463
  1. Donald B. Kaufman,
  2. Roger Katz,
  3. Rawle M. McIntosh

    Abstract

    Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals—3·3 to 0·78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.