Spironolactone Diuresis in Patients with Cirrhosis and AscitesBr Med J 1970; 4 doi: https://doi.org/10.1136/bmj.4.5732.401 (Published 14 November 1970) Cite this as: Br Med J 1970;4:401
- Ronald C. Eggert
Increased aldosterone levels with consequent or diuretic-potentiated electrolyte abnormalities are an important consideration when patients with cirrhosis and ascites undergo diuresis. A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined. Patients with a ratio greater than 1 responded well to 100 mg. of spironolactone a day; those when it was one or less responded well to 200 to 1,000 mg. a day.
Administration of spironolactone alone (11 patients) or as the main diuretic (three patients) was a safe and effective means of inducing sustained uncomplicated diuresis in all these patients.