Papers And Originals

Exercise Asthma and Disodium Cromoglycate

Br Med J 1970; 4 doi: http://dx.doi.org/10.1136/bmj.4.5731.337 (Published 07 November 1970) Cite this as: Br Med J 1970;4:337
  1. H. Poppius,
  2. A. Muittari,
  3. K.-E. Kreus,
  4. O. Korhonen,
  5. A. Viljanen

    Abstract

    Exercise-induced asthma (defined as a fall in PEF of at least 25% of the pre-exercise value) was studied in adult patients with uncomplicated asthma. This was found to occur in 22 out of 52 patients. Pre-exercise inhalation of disodium cromoglycate reduced the mean fall in PEF after maximal exercise from 50% of the pre-exercise value to 23% (open assessment in 11 cases). After submaximal exercise for eight minutes the reduction was from 18% to 10% (double-blind crossover study in 28 cases). It is concluded that disodium cromoglycate partly inhibits the increase of airways resistance after exercise in asthmatic patients.