Antilymphocyte Serum and Tissue Culture Used to Investigate Role of Cell-mediated Response in Viral Encephalitis in MiceBr Med J 1970; 4 doi: https://doi.org/10.1136/bmj.4.5729.210 (Published 24 October 1970) Cite this as: Br Med J 1970;4:210
- G. A. W. Rook,
- H. E. Webb
Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.