Osteomalacia with Long-term Anticonvulsant Therapy in EpilepsyBr Med J 1970; 4 doi: http://dx.doi.org/10.1136/bmj.4.5727.69 (Published 10 October 1970) Cite this as: Br Med J 1970;4:69
- C. E. Dent,
- A. Richens,
- D. J. F. Rowe,
- T. C. B. Stamp
The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy. It is suggested that drug-mediated enzyme induction may be the mechanism responsible by causing a greatly increased inactivation of vitamin D in these patients.