Critical study of 5% guanethidine in ocular manifestations of Graves's diseaseBr Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5684.645 (Published 13 December 1969) Cite this as: Br Med J 1969;4:645
- N. E. F. Cartlidge,
- A. L. Crombie,
- J. Anderson,
- R. Hall
Assessment was made of 5% local guanethidine in treating eye manifestations in euthyroid patients with either treated thyrotoxicosis or ophthalmic Graves's disease. In a double-blind crossover study guanethidine caused greater improvement in lid retraction than a control solution. A long-term study showed that this improvement was maintained. A much lower incidence of side-effects was noted with 5% guanethidine than with 10% solution.