Serum growth hormone levels and size of pituitary tumour in untreated acromegalyBr Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5683.582 (Published 06 December 1969) Cite this as: Br Med J 1969;4:582
- A. D. Wright,
- M. S. F. McLachlan,
- F. H. Doyle,
- T. Russell Fraser
Serum levels of growth hormone were measured in 84 untreated acromegalic patients. The range of mean level during a glucose tolerance test was 8 to 1,860 ng./ml. and was lognormally distributed. Mean level was reproducible and correlated moderately well with maximum sellar area on lateral tomography. The hormone level was more responsive to oral glucose and insulin-induced hypoglycaemia in patients with smaller tumours. Attention is drawn to limitations of plain radiographs in assessing the size of a pituitary tumour. Suprasellar tumour extensions may be present in patients without visual field defects.