Papers And Originals

Platelet aggregation during oral contraception

Br Med J 1969; 4 doi: http://dx.doi.org/10.1136/bmj.4.5678.273 (Published 01 November 1969) Cite this as: Br Med J 1969;4:273
  1. L. Poller,
  2. Celia M. Priest,
  3. Jean M. Thomson

    Abstract

    Platelet aggregation has been found to be significantly accelerated with the coagulation-induced Chandler's tube technique in women taking combined oestrogen-progestin oral contraceptives, though this was less than in the third trimester of pregnancy. Women taking the pure progestogen, chlormadinone acetate, have not shown this change up to the sixth month of study. In contrast the accelerated platelet aggregation resulting from conventional oral contraception became normal one month after changing to the progestogen. There was no change in the platelet aggregation response to adenosine diphosphate (A.D.P.) during oral contraception.

    Footnotes

    • * This work was performed while in receipt of a grant for Thrombosis Research from the Manchester Regional Hospital Board. Supplies of chlormadinone acetate (Normenon) were provided by Syntex Pharmaceuticals Ltd.