Topical ampicillin in the appendicectomy wound: Report of double-blind trialBr Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5677.206 (Published 25 October 1969) Cite this as: Br Med J 1969;4:206
- J. W. S. Rickett,
- B. T. Jackson
One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound. The postoperative wound infection rates were 3% in the ampicillin-treated group and 24% in the control group, a significant difference. This difference was not influenced by the degree of inflammation in the appendix. No side-effects of treatment were observed.